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Our identification of VRK2-mediated SLC7A11 trafficking suggests a potential immune evasion mechanism, as SLC7A11-high tumors often display T cell exclusion phenotypes [37], warranting future investigation into whether VRK2 expression could predict therapeutic response to combined ferroptosis inducers and immune checkpoint inhibitors

Current evidence is strongest for mechanisms in cell culture rather than large-scale human efficacy studies

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5.1 Common adverse effects and adherence gaps The most prevalent adverse effects of GLP-1RAs are gastrointestinal (GI) symptoms, including nausea, vomiting, and diarrhea or constipation

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